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Imiquimod maleate

Names

[ CAS No. ]:
896106-16-4

[ Name ]:
Imiquimod maleate

[Synonym ]:
1H-Imidazo[4,5-c]quinolin-4-amine, 1-(2-methylpropyl)-, (2Z)-2-butenedioate (1:1)
1-Isobutyl-1H-imidazo[4,5-c]quinolin-4-amine (2Z)-2-butenedioate (1:1)

Biological Activity

[Description]:

Imiquimod maleate is an immune response modifier that acts as a toll-like receptor 7agonist.

[Related Catalog]:

Signaling Pathways >> Autophagy >> Autophagy
Signaling Pathways >> Immunology/Inflammation >> Toll-like Receptor (TLR)
Research Areas >> Inflammation/Immunology

[Target]

Toll-like receptor 7


[In Vivo]

In animal models, imiquimod stimulates the innate immune response by increasing NK cell activity, activating macrophages to secretecytokines and nitric oxide, and inducing proliferation and differentiation of B lymphocytes. Imiquimod stimulates the innate immune response through induction, synthesis, and release of cytokines, including interferon-a (IFN-α), interleukin (IL)-6, and tumour necrosis factor (TNF)-α[1].

[References]

[1]. Bilu D, et al. Imiquimod: modes of action. Br J Dermatol. 2003 Nov;149 Suppl 66:5-8.


[Related Small Molecules]

TAK-242 | Chloroquine diphosphate | Resiquimod | TLR2-IN-C29 | imiquimod | Hydroxychloroquine sulfate | GS-9620 | Motolimod | CU CPT 22 | Atractylenolide I | E6446 dihydrochloride | CU-CPT17e | Paquinimod | Gardiquimod trifluoroacetate | Procyanidin B1

Chemical & Physical Properties

[ Molecular Formula ]:
C18H20N4O4

[ Molecular Weight ]:
356.376

[ Exact Mass ]:
356.148468

[ Storage condition ]:
2-8℃

Related Compounds