Monoamine oxidase

Names

[ Name ]:
Monoamine oxidase

[Synonym ]:
EINECS 232-623-0

Biological Activity

[Description]:

Monoamine oxidase is an enzyme composed of different polypeptides. Monoamine oxidation catalyzes the oxidative deamination of various biological amines in brain and peripheral tissues by producing hydrogen peroxide. Monoamine oxidase plays an important role in maintaining the regulation of synaptic transmission, emotional behavior and other brain functions[1][2].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase

Research Areas >> Neurological Disease

[In Vitro]

Monoamine oxidase 有一些同工酶，其中最典型的是单胺氧化酶 (MAO) A 和 MAOB 。MAOA 通常被低浓度氯吉林 (Clorgyline，HY-14197A) 抑制，MAOB 通常被低浓度的 l-盐酸司立吉林抑制[3]。Monoamine oxidase A/B 被贯叶金丝桃中的金丝桃素抑制[4]。

[In Vivo]

Monoamine oxidase 在单胺氧化酶 A 缺陷小鼠脑中，降低了 5-羟色胺 (5-HT) 的浓度，增加了去甲肾上腺素 (NE) 和多巴胺 (DA) 的浓度[1]。

[References]

[1]. Shih JC, et al. Monoamine oxidase: from genes to behavior. Annu Rev Neurosci. 1999;22:197-217.

[2]. Bortolato M, et al. Monoamine oxidase inactivation: from pathophysiology to therapeutics. Adv Drug Deliv Rev. 2008 Oct-Nov;60(13-14):1527-33.

[3]. Youdim MB, et al. The therapeutic potential of monoamine oxidase inhibitors. Nat Rev Neurosci. 2006 Apr;7(4):295-309.

[4]. Suzuki O, et al. Inhibition of monoamine oxidase by hypericin. Planta Med. 1984 Jun;50(3):272-4.