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PIK-293

Names

[ CAS No. ]:
900185-01-5

[ Name ]:
PIK-293

[Synonym ]:
PIK-293-Supplied by Selleck Chemicals
S2207_Selleck
cc-612
2-((4-amino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-methyl-3-o-tolylquinazolin-4(3H)-one
X7412
2-[(4-Amino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl]-5-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone
4(3H)-Quinazolinone, 2-[(4-amino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl]-5-methyl-3-(2-methylphenyl)-
PIK-293

Biological Activity

[Description]:

PIK-293, an analog of IC87114, is a PI3K inhibitor, with IC50 values of 0.24 μM, 10 μM, 25 μM and 100 μM for p110δ, p110β, p110γ and p110α, respectively[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PI3K/Akt/mTOR >> PI3K
Research Areas >> Metabolic Disease

[Target]

PI3Kδ:0.24 μM (IC50)

PI3Kβ:10 μM (IC50)

PI3Kγ:25 μM (IC50)

PI3Kα:100 μM (IC50)


[References]

[1]. Knight ZA, et al. A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling. Cell. 2006 May 19;125(4):733-47.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
657.3±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C22H19N7O

[ Molecular Weight ]:
397.433

[ Flash Point ]:
351.3±34.3 °C

[ Exact Mass ]:
397.165100

[ PSA ]:
104.51000

[ LogP ]:
2.18

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.759

[ Storage condition ]:
-20℃

Related Compounds