Detomidine hydrochloride

Names

[ Name ]:
Detomidine hydrochloride

[Synonym ]:
1H-Imidazole, 5-[(2,3-dimethylphenyl)methyl]-, hydrochloride (1:1)
5-[(2,3-dimethylphenyl)methyl]-1H-imidazole,hydrochloride
4-(2,3-Dimethylbenzyl)-1H-imidazole hydrochloride (1:1)

Biological Activity

[Description]:

Detomidine hydrochloride produce dose-dependent sedative and analgesic effects, is a nonnarcotic, synthetic α2-adrenergic agonistTarget: α2-adrenergic agonistDetomidine is an imidazole derivative and α2-adrenergic agonist, used as a large animal sedative, primarily used in horses. It is usually available as the salt detomidine hydrochloride. It is a prescription medication available to veterinarians sold under the trade name Dormosedan. Currently, detomidine is only licenced for use in horses.Detomidine is a sedative with analgesic properties. α2-adrenergic agonists produce dose-dependent sedative and analgesic effects, mediatated by activation of α2 catecholamine receptors, thus inducing a negative feedback response, reducing production of excitatory neurotransmitters. Due to inhibition of the sympathetic nervous system, detomidine also has cardiac and respiratory effects and an antidiuretic action.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor

Research Areas >> Neurological Disease

[References]

[1]. Virtanen R, et al. Pharmacological evidence for the involvement of alpha-2 adrenoceptors in the sedative effect of detomidine, a novel sedative-analgesic. J Vet Pharmacol Ther. 1985 Mar;8(1):30-7.

[Related Small Molecules]

Chemical & Physical Properties

[ Boiling Point ]:
386.5ºC at 760mmHg

[ Melting Point ]:
160ºC

[ Molecular Formula ]:
C₁₂H₁₅ClN₂

[ Molecular Weight ]:
222.714

[ Flash Point ]:
200.6ºC

[ Exact Mass ]:
222.092377

[ PSA ]:
28.68000

[ LogP ]:
3.41930

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NI5160000

CHEMICAL NAME :: 1H-Imidazole, 4-((2,3-dimethylphenyl)methyl)-, monohydrochloride

CAS REGISTRY NUMBER :: 90038-01-0

LAST UPDATED :: 199009

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C12-H14-N2.Cl-H

MOLECULAR WEIGHT :: 222.74

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 35 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4443466

Safety Information

[ Hazard Codes ]:
Xi

[ RIDADR ]:
UN 2811 6.1 / PGIII

[ RTECS ]:
NI5160000

[ HS Code ]:
2933290090

Customs

[ HS Code ]: 2933290090

[ Summary ]:
2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Atipamezole antagonism of an ACTH stimulation test in ponies sedated with detomidine.

J. Vet. Pharmacol. Ther. 34(5) , 508-11, (2011)

Influence of detomidine and xylazine on spleen dimensions and on splenic response to epinephrine infusion in healthy adult horses.

Vet. Anaesth. Analg. 40(4) , 375-81, (2013)

To compare the changes in splenic length and thickness and in packed cell volume (PCV) following detomidine or xylazine administration and subsequent epinephrine infusion.Spleen relaxation occurs foll...

Comparison of the mechanical hypoalgesic effects of five α2-adrenoceptor agonists in donkeys.

Vet. Rec. 173(12) , 294, (2013)

Pharmacological pain management is necessary under many clinical situations, but in donkeys little information on analgesic drugs is available. This controlled, randomised, crossover, Latin-square, op...