m-PEG-OH (MW 2000)

Names

[ Name ]:
m-PEG-OH (MW 2000)

[Synonym ]:
MFCD00084416
Poly(oxy-1,2-ethanediyl), α-methyl-ω-hydroxy- Polymer
2,5,8,11,14,17,20,23,26,29,32-Undecaoxatetratriacontan-34-ol
Methoxypolyethylene glycols

Biological Activity

[Description]:

m-PEG-OH (MW 2000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Density]:
1.08

[ Boiling Point ]:
557.1±45.0 °C at 760 mmHg

[ Melting Point ]:
12 ºC

[ Molecular Formula ]:
C₂₃H₄₈O₁₂

[ Molecular Weight ]:
516.620

[ Flash Point ]:
268 ºC

[ Exact Mass ]:
516.314575

[ LogP ]:
-4.38

[ Appearance of Characters ]:
semisolid | White to pale yellow

[ Vapour density ]:
>1 (vs air)

[ Vapour Pressure ]:
0.0±3.4 mmHg at 25°C

[ Index of Refraction ]:
1.456

[ Storage condition ]:
?20°C

[ Water Solubility ]:
H2O: 50 mg/mL at 25 °C, clear, colorless

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
PE8271000

Articles

Universal concept for the implementation of a single cleavable unit at tunable position in functional poly(ethylene glycol)s.

Biomacromolecules 14(2) , 448-59, (2013)

Poly(ethylene glycol) (PEG) with acid-sensitive moieties gained attention particularly for various biomedical applications, such as the covalent attachment of PEG (PEGylation) to protein therapeutics,...

Preliminary assessment of the safety evaluation of novel pH-sensitive hydrogel.

Eur. J. Pharm. Biopharm. 82(2) , 332-9, (2012)

In our previous work, a new kind of pH-sensitive hydrogel based on poly (lactic acid) (PLA), methoxyl poly (ethylene glycol) (MPEG) and itaconic acid (IA) was prepared by heat-initiated free radical p...

PEGylation of vesicular stomatitis virus extends virus persistence in blood circulation of passively immunized mice.

J. Virol. 87(7) , 3752-9, (2013)

We are developing oncolytic vesicular stomatitis viruses (VSVs) for systemic treatment of multiple myeloma, an incurable malignancy of antibody-secreting plasma cells that are specifically localized i...