Subtilisin (Compound proteinase)

[Description]:

Subtilisin Compound proteinase (Protamex) is a proteolytic enzyme. Subtilisin Compound proteinase has catalytic activity in anhydrous dimethyl formamide. Subtilisin Compound proteinase can be used as a catalyst for easy coupling between sugars and amino acids[1][2].

[Related Catalog]:

Research Areas >> Others

[In Vitro]

Subtilisin Compound proteinase 在二甲基甲酰胺中选择性的酰化二糖、寡糖、核苷和相关的大分子[1]。 Subtilisin Compound proteinase 在活化的丁酸三氟乙酯 (TFEB) 存在下，可以酰化黄烷醇异槲皮素 (1) 的 D-葡萄糖[3]。 Subtilisin Compound proteinase 改善了蛋白质和脂肪酸的溶解度，恢复了多肽和不饱和脂肪酸[4]。

[In Vivo]

Subtilisin Compound proteinase 水解产物 (150 mg/kg 和 300 mg/kg；口服；一天一次持续 6 周) (≤1 kDa 的葡糖乳蛋白水解物，MLPH) 对 ob/ob 小鼠具有抗肥胖和抗高血糖作用[4]。

[References]

[1]. Riva S, et al. Protease-catalyzed regioselective esterification of sugars and related compounds in anhydrous dimethylformamide[J]. Journal of the American Chemical Society, 1988, 110(2): 584-589.

[2]. Philipp M, et al. Inhibition of subtilisin by substituted arylboronic acids. FEBS Lett. 1981 Oct 12;133(1):36-8.

[3]. Danieli B, et al. On the regioselectivity of the protease subtilisin towards the acylation of enantiomeric pairs of benzyl and naphthyl glycopyranosides. Part 2[J]. Tetrahedron, 1999, 55(7): 2045-2060.

[4]. Kim MJ, et al. Anti-Obesity and Anti-Hyperglycemic Effects of Meretrix lusoria Protamex Hydrolysate in ob/ob Mice. Int J Mol Sci. 2022 Apr 5;23(7):4015.

[ Density]:
1.3

[ Molecular Formula ]:
C₁₁H₉N₃O_2.Na

[ Molecular Weight ]:
238.19786

[ Appearance of Characters ]:
powder | white

[ Storage condition ]:
2-8°C

[ Stability ]:
store cold

[ Symbol ]:

GHS05, GHS07, GHS08, GHS09

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H315-H318-H334-H335-H410

[ Precautionary Statements ]:
P261-P273-P280-P305 + P351 + P338-P342 + P311

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn,N

[ Risk Phrases ]:
37/38-41-42-36/37/38-50-22

[ Safety Phrases ]:
23-24-26-36/37/39-22-36/37-61-45-39

[ RIDADR ]:
3082

[ WGK Germany ]:
2

[ RTECS ]:
UK9540000

[ HS Code ]:
35079090

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