GPVI antagonist 3

Names

[ CAS No. ]:
901654-94-2

[ Name ]:
GPVI antagonist 3

Biological Activity

[Description]:

GPVI antagonist 3 (Compound 2) is a potential antagonist of Glycoprotein VI (GPVI). IC50 values of GPVI antagonist 3 are, respectively, 1.01 μM for collagen, 1.92 μM for CRP, 7.24 μM for convulxin and 51.74 μM for thrombin. Glycoprotein VI (GPVI) is a platelet major collagen receptor and a target for potent and safe antithrombotic research. GPVI antagonist 3 is a promising antiplatelet agent[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> Others >> Others

[References]

[1]. Olğaç S, et al. Identification of novel antiplatelet agents by targeting Glycoprotein VI: A combined virtual screening study. Bioorg Chem. 2022;121:105661.

Chemical & Physical Properties

[ Molecular Formula ]:
C22H23N3O4

[ Molecular Weight ]:
393.44

Related Compounds