Cholesterol esterase

Names

[ Name ]:
Cholesterol esterase

[Synonym ]:
Biocatalytics E3
4,10-Diacetoxy-1,7,9-trihydroxy-13-({2-hydroxy-3-[(4-hydroxybenzoyl)amino]-3-phenylpropanoyl}oxy)-5,20-epoxytax-11-en-2-yl benzoate
Bucelipase alfa
Bile salt-stimulated lipase
MFCD00071052
Benzenepropanoic acid, α-hydroxy-β-[(4-hydroxybenzoyl)amino]-, 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,5,11-trihydroxy-4a,8,13,13-tetramethyl-7,11-me thano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester

Biological Activity

[Description]:

Cholesterol esterase is an enzyme that hydrolyzes cholesterol ester to cholesterol and free fatty acid in the intestinal lumen. Cholesterol synthesized in the acinar cells and is stored in zymogen granules. Cholesterol esterase is also known as bile salt-stimulated lipase and carboxy ester lipasea, acts function for acceleration of cholesterol absorption[1][2].

[Related Catalog]:

Research Areas >> Metabolic Disease

[References]

[1]. Ikeda I, et al. Cholesterol esterase accelerates intestinal cholesterol absorption. Biochim Biophys Acta. 2002 May 10;1571(1):34-44.

[2]. Myers-Payne SC, et al. Cholesterol esterase: a cholesterol transfer protein. Biochemistry. 1995 Mar 28;34(12):3942-7.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
982.8±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₄₇H₅₃NO₁₅

[ Molecular Weight ]:
871.921

[ Flash Point ]:
548.2±34.3 °C

[ Exact Mass ]:
871.341492

[ LogP ]:
5.68

[ Appearance of Characters ]:
powder | white

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.651

[ Storage condition ]:
−20°C

[ Water Solubility ]:
Dissolve 1mg/ml in 0.1M phosphate buffer, pH 6.0 to 7.0

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
22-24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

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