Pantothenate Kinase Inhibitor

Names

[ Name ]:
Pantothenate Kinase Inhibitor

[Synonym ]:
MFCD14776926
3-(2,4-Dimethylpyrido[2',3':3,4]pyrazolo[1,5-a]pyrimidin-3-yl)-N-[3-(methylsulfanyl)phenyl]propanamide
Pantothenate Kinase Inhibitor
Pyrido[2',3':3,4]pyrazolo[1,5-a]pyrimidine-3-propanamide, 2,4-dimethyl-N-[3-(methylthio)phenyl]-

Biological Activity

[Description]:

Pantothenate kinase-IN-2 is a potent Pantothenate kinase 1/3 (PanK1/3) inhibitor with an IC50 of 0.14 μM and 0.36 μM. Pantothenate kinase-IN-2 is a promising agent for PKAN (PanK-associated neurodegeneration) and diabetes research[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

[Target]

IC50: 0.14 μM (PanK1); 0.36 μM (PanK3)[1]

[References]

[1]. Lalit Kumar Sharma, et al. A high-throughput screen reveals new small-molecule activators and inhibitors of pantothenate kinases. J Med Chem. 2015 Feb 12;58(3):1563-8.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Molecular Formula ]:
C₂₁H₂₁N₅OS

[ Molecular Weight ]:
391.49

[ Exact Mass ]:
391.146667

[ LogP ]:
3.98

[ Index of Refraction ]:
1.694

[ Storage condition ]:
2-8°C

Pantothenate Kinase Inhibitor

Names

Biological Activity

Chemical & Physical Properties

Related Compounds