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Psoralenoside

Names

[ CAS No. ]:
905954-17-8

[ Name ]:
Psoralenoside

[Synonym ]:
(2Z)-3-[6-(β-D-Glucopyranosyloxy)-1-benzofuran-5-yl]acrylic acid
2-Propenoic acid, 3-[6-(β-D-glucopyranosyloxy)-5-benzofuranyl]-, (2Z)-

Biological Activity

[Description]:

Psoralenoside is a benzofuran glycoside from Psoralea corylifolia[1]. Psoralenoside exhibits high binding affinities against histaminergic H1, calmodulin, and voltage-gated L-type calcium channels (E-value≥-6.5 Kcal/mol)[2]. Psoralenoside shows estrogen-like activity, osteoblastic proliferation accelerating activity, antitumor effects and antibacterial activity[3].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel
Research Areas >> Cancer
Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor
Signaling Pathways >> Neuronal Signaling >> CaMK
Research Areas >> Infection
Research Areas >> Metabolic Disease
Signaling Pathways >> GPCR/G Protein >> Histamine Receptor

[Target]

H1 Receptor

L-type calcium channel


[References]

[1]. Chun-Feng Qiao, et al.Psoralenoside and isopsoralenoside, two new benzofuran glycosides from Psoralea corylifolia. Chem Pharm Bull (Tokyo). 2006 May;54(5):714-6.

[2]. Muhammad Bilal Riaz, et al. Pharmacological and computational evaluation of fig for therapeutic potential in hyperactive gastrointestinal disorders. BMC Complement Altern Med. 2019 Dec 3;19(1):348.

[3]. Yue-Fei Wang, et al.A UPLC-MS/MS method for in vivo and in vitro pharmacokinetic studies of psoralenoside, isopsoralenoside, psoralen and isopsoralen from Psoralea corylifolia extract. J Ethnopharmacol

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
662.4±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C17H18O9

[ Molecular Weight ]:
366.319

[ Flash Point ]:
354.4±31.5 °C

[ Exact Mass ]:
366.095093

[ LogP ]:
-0.02

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.711

Related Compounds