MI-223
Names
[ CAS No. ]:
907166-59-0
[ Name ]:
MI-223
Biological Activity
[Description]:
MI-223 (NSC 320223) is a small molecule that specifically binds to Mcl-1 with Kd of 160 nM, inhibits HR DNA repair and sensitizes cancer cells to DNA replication agents; not only disrupts the Mcl-1/Ku complex, but also potently inhibits HR activity in both H1299 and U2OS DR-GFP cells in a dose-dependent manner, sensitizes cancer cells to hydroxyurea- or olaparib-induced DNA replication stress; exhibits a strong synergy against lung cancer in vivo combined with Olaparib.
[References]
References 1. Chen G, et al. J Clin Invest. 2018 Jan 2;128(1):500-516. View Related Products by Target Bcl-2
Chemical & Physical Properties
[ Molecular Formula ]:
C23H18ClN3O3
[ Molecular Weight ]:
419.865