m-PEG6-2-methylacrylate

Names

[ CAS No. ]:
90784-86-4

[ Name ]:
m-PEG6-2-methylacrylate

Biological Activity

[Description]:

m-PEG6-2-methylacrylate is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. Zhu C, et al. Reversibly shielded DNA polyplexes based on bioreducible PDMAEMA-SS-PEG-SS-PDMAEMA triblock copolymers mediate markedly enhanced nonviral gene transfection. Biomacromolecules. 2012 Mar 12;13(3):769-78.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₃₂O₈

[ Molecular Weight ]:
364.43

m-PEG6-2-methylacrylate

Names

Biological Activity

Chemical & Physical Properties

Related Compounds