N-Deshydroxyethyl Dasatinib

Names

[ Name ]:
N-Deshydroxyethyl Dasatinib

[Synonym ]:
N-(2-CHLORO-6-METHYLPHENYL)-2-[[2-METHYL-6-(PIPERAZIN-1-YL)-PYRIMIDIN-4-YL]AMINO]-5-THIAZOLECARBOXAMIDE
Dasatinib metabolite M4
N-(2-chloro-6-methylphenyl)-2-(2-methyl-6-(piperazin-1-yl)pyrimidin-4-ylamino)thiazole-5-carboxamide
N-(2-chloro-6-methylphenyl)-2-[[2-methyl-6-(1-piperazinyl)-4-pyrimidinyl]amino]-5-thiazolecarboxamide
N-Deshydroxyethyl Dasatinib
Dasatinib Impurity 6
Target Protein-binding moiety 8

Biological Activity

[Description]:

Target Protein-binding moiety 8 is a compound binding to BCR-ABL, and used for inhibiting BCR-ABL activity.

[Related Catalog]:

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Bcr-Abl

Signaling Pathways >> PROTAC >> PROTAC

Research Areas >> Cancer

[Target]

BCR-ABL[1]

[In Vitro]

Target Protein-binding moiety 8 (Compound 8) is a compound binding to BCR-ABL, and used for inhibiting BCR-ABL activity.

[References]

[1]. Shibata N, et al. Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands. Cancer Sci. 2017 Aug;108(8):1657-1666.

[Related Small Molecules]

Nocodazole | ARV-771 | ARV-825 | Asciminib | dBET1 | Degrasyn(WP1130) | Bafetinib (INNO-406) | DCC-2036 (Rebastinib) | Protein degrader 1 hydrochloride | dBET6 | KW-2449 | AST 487 | Mz1 | PD173955 | XL228

Chemical & Physical Properties

[ Density]:
1.404g/cm3

[ Melting Point ]:
>300ºC

[ Molecular Formula ]:
C₂₀H₂₂ClN₇OS

[ Molecular Weight ]:
443.95300

[ Exact Mass ]:
443.13000

[ PSA ]:
123.31000

[ LogP ]:
4.14860

[ Index of Refraction ]:
1.69

N-Deshydroxyethyl Dasatinib

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds