<Suppliers Price>

Piperaquine tetraphosphate

Names

[ CAS No. ]:
911061-10-4

[ Name ]:
Piperaquine tetraphosphate

[Synonym ]:
UNII-IHB5WLO51Q
Piperaquine tetraphosphate

Biological Activity

[Description]:

Piperaquine tetraphosphate is a potent antimalaria agent. Piperaquine tetraphosphate shows inhibition for chloroquine-sensitive and the chloroquine-resistant isolates. Piperaquine tetraphosphate in combination with dihydroartemisinin has the potential for the research of chloroquine-resistant malaria[1][2].

[Related Catalog]:

Research Areas >> Infection

[In Vitro]

Piperaquine tetraphosphate shows high active against all Cameroonian isolates with IC50 of 38.9 nM, range, 7.76-78.3 nM, and shows inhibits against the chloroquine-sensitive and the chloroquine-resistant isolates[1].

[References]

[1]. asco LK, et al. In vitro activities of piperaquine and other 4-aminoquinolines against clinical isolates of Plasmodium falciparum in Cameroon. Antimicrob Agents Chemother. 2003 Apr;47(4):1391-4.

[2]. Salman S,et al. Pharmacokinetic comparison of two piperaquine-containing artemisinin combination therapies in Papua New Guinean children with uncomplicated malaria. Antimicrob Agents Chemother. 2012 Jun;56(6):3288-97.

Chemical & Physical Properties

[ Molecular Formula ]:
C29H44Cl2N6O16P4

[ Molecular Weight ]:
927.49100

[ Exact Mass ]:
926.11400

[ PSA ]:
389.02000

[ LogP ]:
1.71550

Related Compounds