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13C15-Nivalenol

Names

[ CAS No. ]:
911392-40-0

[ Name ]:
13C15-Nivalenol

[Synonym ]:
13C15-Nivalenol
Trichothec-9-en-8-one-2,3,4,5,6,7,8,9,10,11,12,13,14,15,16-13C15, 12,13-epoxy-3,4,7,15-tetrahydroxy-, (2α,3α,4β,7α,12α)-
(3α,4β,7α)-3,4,7,15-Tetrahydroxy(2,3,4,5,6,7,8,9,10,11,12,13,14,15,16-13C15)-12,13-epoxytrichothec-9-en-8-one

Biological Activity

[Description]:

Nivalenol-13C15 is the 13C labeled Nivalenol (HY-N6801)[1]. Nivalenol, classified as type B trichotecenes toxins produced by Fusarium graminearum, is a fungal metabolite present in agricultural product[2]. Nivalenol induces cell death through caspase-dependent mechanisms and via the intrinsic apoptotic pathway. Nivalenol affects the immune system, causes emesis, growth retardation, reproductive disorders and has a haematotoxic/myelotoxic effect[3].

[Related Catalog]:

Research Areas >> Infection

[Target]

caspase[2]


[In Vitro]

氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱[1]。

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Molecular Formula ]:
13C15H20O7

[ Molecular Weight ]:
327.20

[ Exact Mass ]:
327.171234

[ Index of Refraction ]:
1.658

Safety Information

[ Symbol ]:

GHS02, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H302 + H312 + H332-H319

[ Precautionary Statements ]:
P210-P280-P305 + P351 + P338

[ Hazard Codes ]:
T+

[ RIDADR ]:
UN 1648 3 / PGII

Related Compounds