UDP-α-D-N-Acetylglucosamine Disodium Salt

Names

[ Name ]:
UDP-α-D-N-Acetylglucosamine Disodium Salt

[Synonym ]:
URIDINE 5-DIPHOSPHO-N-ACETYLGLUCOSAMINE
MFCD00799985
UDPAG SODIUM SALT
UDP-GlcNAc disodium salt
EINECS 293-820-5
UDP-A-D-N-ACETYL-GLUCOSAMINE
UDPAG
UDP-GLCNAC,2NA
UDP-GLCNAC,NA2
UDP-N-ACETYLGLUCOSAMINE DISODIUM SALT
UDP-N-acetyl-D-glucosamine disodium salt
udp-glcnac
uridine 5'-diphosphate-N-acetylglucosamine disodium salt
UDP-α-D-N-Acetylglucosamine Disodium Salt

Biological Activity

[Description]:

UDP-GlcNAc Disodium Salt is a donor substrate of O-GlcNAc transferase (OGT).

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

[In Vitro]

OGT is a nucleocytoplasmic glycosyltransferase (uridine diphospho-N--acetylglucosamine:polypeptide β-N-acetylglucosaminyltransferase or O-GlcNAc transferase) assigned to the GT41 family in the CAZY (Carbohydrate-Active enZYme) database. Using UDP-GlcNAc Disodium Salt (UDP-GlcNAc) as the donor substrate, this enzyme modifies thousands of proteins by adding a unique N-acetylglucosamine residue onto acceptor substrates mainly confined within cytosol and nucleus[1].

[References]

[1]. Lefebvre T, et al. Antibodies and activity measurements for the detection of O-GlcNAc transferase and assay of its substrate, UDP-GlcNAc. Methods Mol Biol. 2013;1022:147-59.

[Related Small Molecules]

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₂₅N₃Na₂O₁₇P₂

[ Molecular Weight ]:
651.31700

[ Exact Mass ]:
651.04500

[ PSA ]:
331.14000

[ Storage condition ]:
−20°C

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
22-26-36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
29349990

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Transporter-mediated uptake of UDP-glucuronic acid by human liver microsomes: assay conditions, kinetics, and inhibition.

Drug Metab. Dispos. 43(1) , 147-53, (2014)

This study characterized the kinetics, variability, and factors that affect UDP-glucuronic acid (UDP-GlcUA) uptake by human liver microsomes (HLM). Biphasic kinetics were observed for UDP-GlcUA uptake...

Enhanced transfer of a photocross-linking N-acetylglucosamine (GlcNAc) analog by an O-GlcNAc transferase mutant with converted substrate specificity.

J. Biol. Chem. 290 , 22638-48, (2015)

O-Linked β-N-acetylglucosamine (O-GlcNAc) is a post-translational modification of proteins in multicellular organisms. O-GlcNAc modification is catalyzed by the O-GlcNAc transferase (OGT), which trans...

A new antibiotic kills pathogens without detectable resistance.

Nature 517(7535) , 455-9, (2015)

Antibiotic resistance is spreading faster than the introduction of new compounds into clinical practice, causing a public health crisis. Most antibiotics were produced by screening soil microorganisms...