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Azido-PEG10-amine

Names

[ CAS No. ]:
912849-73-1

[ Name ]:
Azido-PEG10-amine

[Synonym ]:
O-(2-Aminoethyl)-O'-(2-azidoethyl)nonaethylene glycol
Azido-PEG-amine (n=10)
32-Azido-3,6,9,12,15,18,21,24,27,30-decaoxadotriacontan-1-amine
O-(2-Aminoethyl)-O inverted exclamation marka-(2-azidoethyl)nonaethylene glycol
Azido-PEG10-amine

Biological Activity

[Description]:

Azido-PEG10-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Molecular Formula ]:
C22H46N4O10

[ Molecular Weight ]:
526.62100

[ Exact Mass ]:
526.32100

[ PSA ]:
168.07000

[ LogP ]:
0.57446

[ Storage condition ]:
2-8°C

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Related Compounds