(22R)-14,20,22-Trihydroxy-1-oxoergosta-3,5,24-triene-18,26-dioic acid 18,20:26,22-dilactone

Names

[ Name ]:
(22R)-14,20,22-Trihydroxy-1-oxoergosta-3,5,24-triene-18,26-dioic acid 18,20:26,22-dilactone

[Synonym ]:
1-(4-Chlorophenyl)-2-methyl-6-phenyl-4(1H)-pyridinone
4(1H)-Pyridinone, 1-(4-chlorophenyl)-2-methyl-6-phenyl-

Biological Activity

[Description]:

Withaphysalin D is a selective antagonist against the N-methyl-D-aspartate receptor (NMDAR) containing GluN2B. Withaphysalin D can be isolated from water lilies and has neuroprotective properties. Withaphysalin D is able to cross the blood-brain barrier[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> iGluR

Research Areas >> Neurological Disease

Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR

[References]

[1]. Kumar G,et al. Exploring neuroprotective potential of Withania somnifera phytochemicals by inhibition of GluN2B-containing NMDA receptors: An in silico study. Med Hypotheses. 2016 Jul;92:35-43.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
451.6±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₈H₁₄ClNO

[ Molecular Weight ]:
295.763

[ Flash Point ]:
226.9±28.7 °C

[ Exact Mass ]:
295.076385

[ LogP ]:
4.22

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.631