Resolvin D3

Resolvin D3 (RvD3) is a docosahexaenoic acid (DHA) derived mediator. Resolvin D3 is dysregulated in arthritis and reduces arthritic inflammation[1][2].

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

RvD3 (RvD3; 10 nM) significantly inhibits tumor necrosis factor-α–induced NF-κB activation in A549 epithelial cells[2].

Resolvin D3 (RvD3; 100 ng/100 µl; IP; daily for 6 days) alleviates arthritis progression, reduces edema and limits leukocyte numbers in murine K/BxN-serum induced arthritis[1]. Animal Model: Male C57Bl/6 mice (12 weeks old) or ALX/fpr2/3 KO mice[1] Dosage: 100 ng/100 µl Administration: IP; daily for 6 days Result: Alleviated arthritis progression, reduced edema and limited leukocyte numbers in murine K/BxN-serum induced arthritis.

[1]. Hildur H Arnardottir, et al. Resolvin D3 Is Dysregulated in Arthritis and Reduces Arthritic Inflammation. J Immunol. 2016 Sep 15;197(6):2362-8.

[2]. Jennifer K Colby, et al. Resolvin D3 and Aspirin-Triggered Resolvin D3 Are Protective for Injured Epithelia. Am J Pathol. 2016 Jul;186(7):1801-1813.