CCMI

Names

[ Name ]:
CCMI

[Synonym ]:
MFCD18086897

Biological Activity

[Description]:

CCMI is a potent and selective α7 nAChR-positive allosteric modulator, does not bind to or activate α7 nAChRs via the orthosteric site, and causes significant positive modulation of agonist-induced currents at α7 nAChRs. CCMI has potential in CNS diseases with cognitive dysfunction[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR

Signaling Pathways >> Neuronal Signaling >> nAChR

Research Areas >> Neurological Disease

[Target]

α7 nAChR[1]

[In Vitro]

CCMI (Compound 6) is a potent and selective α7 nAChR-positive allosteric modulator, does not bind to or activate α7 nAChRs via the orthosteric site, and causes significant positive modulation of agonist-induced currents at α7 nAChRs[1].

[References]

[1]. Ng HJ, et al. Nootropic alpha7 nicotinic receptor allosteric modulator derived from GABAA receptor modulators. Proc Natl Acad Sci U S A. 2007 May 8;104(19):8059-64. Epub 2007 Apr 30.

Chemical & Physical Properties

[ Density]:
1.412±0.06 g/cm3(Predicted)

[ Boiling Point ]:
605.4±55.0 °C

[ Molecular Formula ]:
C₁₉H₁₅Cl₂N₃O₂

[ Molecular Weight ]:
388.24700

[ Exact Mass ]:
387.05400

[ PSA ]:
67.16000

[ LogP ]:
5.52750

Safety Information

[ Hazard Codes ]:
Xn