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N-methyl-N-dithiocarboxyglucamine sodium

Names

[ CAS No. ]:
91840-27-6

[ Name ]:
N-methyl-N-dithiocarboxyglucamine sodium

[Synonym ]:
N-Mgdc
N-Methyl-D-glucamin dithiocarbamate
N-Methyl-N-dithiocarboxyglucamine sodium
Sodium N-methyl-D-glucamine-N-carbodithioate
n-methyl-d-glucaminedithiocarbamate
Sodium N-methyl-D-glucamine dithiocarbamate
D-glucitol-1-yl-methyl-dithiocarbamic acid,sodium salt
NorathiolTM

Biological Activity

[Description]:

N-methyl-N-dithiocarboxyglucamine (MDCG) sodium mobilizes and promotes excretion of metallothionein-bound 109Cd in mouse model. N-methyl-N-dithiocarboxyglucamine significantly lowers the Cd content of both the liver and kidney, which is organs most susceptible to Cd-induced toxicity[1].

[Related Catalog]:

Research Areas >> Others

[In Vivo]

N-methyl-N-dithiocarboxyglucamine (1.1 mM/kg；腹腔注射；单剂量) 可显著诱导 Cd 从粪便排泄。而增加处理次数到每周 7 次后，导致小鼠全身 Cd 负荷减少了 50% 以上[1]。

[References]

[1]. Gale GR, et al. Effects of sodium N-methyl-N-dithiocarboxyglucamine on cadmium distribution and excretion. Life Sci. 1984 Dec 17;35(25):2571-8.  

Chemical & Physical Properties

[ Boiling Point ]:
529.9ºC at 760mmHg

[ Melting Point ]:
232-233ºC

[ Molecular Formula ]:
C8H16NNaO5S2

[ Molecular Weight ]:
293.34

[ Flash Point ]:
274.3ºC

[ Exact Mass ]:
311.04700

[ PSA ]:
171.01000

Safety Information

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26-36

Related Compounds