SARS-CoV-2 nsp13-IN-4

Names

[ CAS No. ]:
923140-39-0

[ Name ]:
SARS-CoV-2 nsp13-IN-4

Biological Activity

[Description]:

SARS-CoV-2 nsp13-IN-4 (C4 (d)) is a potent and selective nsp13 helicase small-molecule inhibitor and inhibit the ssDNA+ ATPase activity of nsp13 with an IC50 value of 57 μM. SARS-CoV-2 nsp13-IN-4 is druglike molecule with molecular weight of less than 450Da and can provide a broad-spectrum antiviral effect[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> SARS-CoV

[Target]

IC50: 57 μM (nsp13 ssDNA+ ATPase) [1]


[In Vitro]

SARS-CoV-2 nsp13-IN-4 (C4 (d)) inhibits the ssDNA+ ATPase activity and the ssDNA− ATPase activity of nsp13 with IC50 values of 57 μM and 240 μM, respectively[1].

[References]

[1]. Aliakbar Khalili Yazdi, et al. Kinetic Characterization of SARS-CoV-2 nsp13 ATPase Activity and Discovery of Small-Molecule Inhibitors. ACS Infect Dis. 2022 Jul 13.

Chemical & Physical Properties

[ Molecular Formula ]:
C20H15BrN4O

[ Molecular Weight ]:
407.26

Related Compounds