2-Phenyl-2-(1-piperidinyl)propane

Names

[ Name ]:
2-Phenyl-2-(1-piperidinyl)propane

[Synonym ]:
N-<1-Methyl-1-phenyl-aethyl>-piperidin

Biological Activity

[Description]:

2-Phenyl-2-(1-piperidinyl)propane is a selective and reversible human CYP2B6 inhibitor with an IC50 of 5.1 μM and a Ki of 5.6. 2-Phenyl-2-(1-piperidinyl)propane inhibits CYP2D6 (IC50=74 μM), CYP3A (IC50=200 μM)[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450

Research Areas >> Metabolic Disease

[Target]

CYP2B6:5.1 μM (IC50)

CYP2B6:5.6 μM (Ki)

CYP2D6:74 μM (IC50)

CYP3A:200 μM (IC50)

CYP1A2:>300 μM (IC50)

CYP2A6:>300 μM (IC50)

CYP2C8:>300 μM (IC50)

CYP2C9:>300 μM (EC50)

CYP2C19:>300 μM (IC50)

CYP2E1:>300 μM (IC50)

[References]

[1]. Walsky RL, et al. A comparison of 2-phenyl-2-(1-piperidinyl)propane (ppp), 1,1',1''-phosphinothioylidynetrisaziridine (thioTEPA), clopidogrel, and ticlopidine as selective inactivators of human cytochrome P450 2B6. Drug Metab Dispos. 2007 Nov;35(11):2053-9.

Chemical & Physical Properties

[ Density]:
0.969g/cm3

[ Boiling Point ]:
271.1ºC at 760 mmHg

[ Molecular Formula ]:
C₁₇H₁₆O₃S

[ Molecular Weight ]:
300.37200

[ Flash Point ]:
107.6ºC

[ Exact Mass ]:
300.08200

[ PSA ]:
68.67000

[ LogP ]:
3.97700

[ Index of Refraction ]:
1.528

[ Storage condition ]:
2-8°C

Safety Information

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26-36

[ HS Code ]:
2933399090

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%