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DUBs-IN-3

Names

[ CAS No. ]:
924296-17-3

[ Name ]:
DUBs-IN-3

[Synonym ]:
DUBs-IN-3

Biological Activity

[Description]:

DUBs-IN-3 is a potent deubiquitinase (USP) enzyme inhibitor extracted from reference compound 22c with an IC50 of 0.56 μM for USP8.

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Deubiquitinase
Research Areas >> Cancer

[Target]

IC50: 0.56 μM (USP8)[1]


[References]

[1]. Colombo M, et al. Synthesis and biological evaluation of 9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile analogues as potential inhibitors of deubiquitinating enzymes. ChemMedChem. 2010 Apr 6;5(4):552-8.


[Related Small Molecules]

BAY 11-7082 | P5091 | PR-619 | VLX1570 | Degrasyn(WP1130) | P 22077 | DUBs-IN-2 | ML364 | NSC 687852 | GNE-6776 | ML 323 | HBX 19818 | IU1 | LDN-57444

Chemical & Physical Properties

[ Density]:
1.31g/cm3

[ Boiling Point ]:
560.4ºC at 760 mmHg

[ Molecular Formula ]:
C16H9N5O

[ Molecular Weight ]:
287.27600

[ Flash Point ]:
292.7ºC

[ Exact Mass ]:
287.08100

[ PSA ]:
94.95000

[ LogP ]:
2.15536

[ Index of Refraction ]:
1.684

Related Compounds