NH2-PEG3 hydrochloride

Names

[ CAS No. ]:
92505-84-5

[ Name ]:
NH2-PEG3 hydrochloride

[Synonym ]:
MFCD28963473

Biological Activity

[Description]:

NH2-PEG3 hydrochloride is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Molecular Formula ]:
C₆H₁₆ClNO₃

[ Molecular Weight ]:
185.64900

[ Exact Mass ]:
185.08200

[ PSA ]:
64.71000

[ LogP ]:
0.47290

NH2-PEG3 hydrochloride

Names

Biological Activity

Chemical & Physical Properties

Related Compounds