Skinasensyl

Names

[ Name ]:
Skinasensyl

[Synonym ]:
N-Acetyl-L-tyrosyl-L-prolyl-L-phenylalanyl-L-phenylalaninamide
L-Phenylalaninamide, N-acetyl-L-tyrosyl-L-prolyl-L-phenylalanyl-
Acetyl tetrapeptide 15

Biological Activity

[Description]:

Acetyl tetrapeptide-15 is a synthetic peptide used in the cosmetics for sensitive skin. Acetyl tetrapeptide-15 is derived from endomorphin-2 (Tyr-Pro-Phe-Phe-NH2), a human μ-opioid agonist with selective anti-nociceptive effect. Acetyl tetrapeptide-15 reduces skin hyperreactivity producing inflammatory, chronic and neuropathic pain, by increasing the threshold of neuronal excitability in μ-opioid receptor via an endorphin-like pathway[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Opioid Receptor

Signaling Pathways >> Neuronal Signaling >> Opioid Receptor

Research Areas >> Neurological Disease

[References]

[1]. Resende DISP, et al. Usage of Synthetic Peptides in Cosmetics for Sensitive Skin. Pharmaceuticals (Basel). 2021;14(8):702.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
1055.3±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃₄H₃₉N₅O₆

[ Molecular Weight ]:
613.703

[ Flash Point ]:
592.0±34.3 °C

[ Exact Mass ]:
613.290039

[ LogP ]:
2.72

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.617

Safety Information

[ Hazard Codes ]:
Xi