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AS 1892802

Names

[ CAS No. ]:
928320-12-1

[ Name ]:
AS 1892802

Biological Activity

[Description]:

AS1892802 is a potent, orally active, and highly selective inhibitor of ROCK. The onset of antinociceptive effect of AS1892802 is as fast as those of Tramadol and Diclofenac. AS1892802 did not induce gastric irritation or abnormal behavior. AS1892802 is an attractive analgesic profile for the research of severe osteoarthritis pain[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> ROCK
Research Areas >> Neurological Disease
Signaling Pathways >> Stem Cell/Wnt >> ROCK
Signaling Pathways >> TGF-beta/Smad >> ROCK

[References]

[1]. Yoshimi E, et al. Antinociceptive effects of AS1892802, a novel Rho kinase inhibitor, in rat models of inflammatory and noninflammatory arthritis. J Pharmacol Exp Ther. 2010;334(3):955-963.

Chemical & Physical Properties

[ Density]:
1.256±0.06 g/cm3 (20 °C, 760 mmHg)

[ Boiling Point ]:
531.2±50.0 °C (760 mmHg)

[ Molecular Formula ]:
C20H19N3O2

[ Molecular Weight ]:
333.38400

[ Exact Mass ]:
333.14800

[ PSA ]:
74.25000

[ LogP ]:
4.06760

Related Compounds