3',4'-DICHLOROBENZAMIL HYDROCHLORIDE

[ Molecular Formula ]:
C₁₃H₁₃Cl₄N₇O

[ Molecular Weight ]:
425.1

[ Appearance of Characters ]:
solid

[ Storage condition ]:
2-8°C

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
22

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Amiloride derivatives are potent blockers of KATP channels.

Naunyn Schmiedebergs Arch. Pharmacol. 364(4) , 351-8, (2001)

In cardiomyocytes sarcolemmal KATP channels open massively when the cytosolic [ATP] drops into the range of tens of micromolar, as during acute ischemia. The diuretic drug amiloride and related deriva...

Modulation of neuroprotective effect of ischemic post-conditioning by dichlorobenzamil a Na(+)/Ca(2+) exchanger inhibitor in mice.

Biol. Pharm. Bull. 33(4) , 585-91, (2010)

The present study has been designed to investigate the modulatory role of dichlorobenzamil a Na(+)/Ca(2+) exchanger inhibitor in ischemic post-conditioning-induced neuroprotection in mice. Bilateral c...

Stimulation of large-conductance Ca2+-activated K+ channels by the Na+/Ca2+ exchanger inhibitor dichlorobenzamil in cultured human umbilical vein endothelial cells and mouse aortic smooth muscle cells.

J. Physiol. Pharmacol. 60(1) , 43-50, (2009)

We investigated the effects of the selective inhibitor of Na(+)/Ca(2+) exchanger (NCX), 2',4'- and 3',4'-dichlorobenzamil (DCB), on large-conductance Ca(2+)-activated K(+) (BK(Ca)) channels in culture...

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