Fasnall

Names

[ Name ]:
Fasnall

[Synonym ]:
Fasnall benzenesulfonate salt
5,6-Dimethyl-N-[1-(phenylmethyl)-3-pyrrolidinyl]thieno[2,3-d]pyrimidin-4-amine benzenesulfonate
N-(1-Benzylpyrrolidin-3-yl)-5,6-dimethylthieno[2,3-d] pyrimidin-4-amine benzenesulfonate
N-(1-Benzyl-3-pyrrolidinyl)-5,6-dimethylthieno[2,3-d]pyrimidin-4-amine benzenesulfonate (1:1)
Fasnall (benzenesulfonate)
Thieno[2,3-d]pyrimidin-4-amine, 5,6-dimethyl-N-[1-(phenylmethyl)-3-pyrrolidinyl]-, benzenesulfonate (1:1)

Biological Activity

[Description]:

Fasnall is a selective fatty acid synthase (FASN) inhibitor with an IC50 of 3.71 μM. Fasnall induces apoptosis in HER2+ breast cancer cell lines. Fasnall shows potent anti-tumor activities[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> Fatty Acid Synthase (FAS)

[Target]

IC50: 3.71 μM (human purified FASN activity)[1]

[References]

[1]. Yazan Alwarawrah, et al. Fasnall, a Selective FASN Inhibitor, Shows Potent Anti-tumor Activity in the MMTV-Neu Model of HER2(+) Breast Cancer. Cell Chem Biol. 2016 Jun 23;23(6):678-88.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₂₂N₄S

[ Molecular Weight ]:
338.47

[ Exact Mass ]:
496.160278