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IA-Alkyne

Names

[ CAS No. ]:
930800-38-7

[ Name ]:
IA-Alkyne

[Synonym ]:
MFCD18839149

Biological Activity

[Description]:

IA-Alkyne (Iodoacetamide-alkyne; N-Hex-5-ynyl-2-iodo-acetamide) is a TRP channel (TRPC) agonist and has the potential for the study of respiratory infection[1]. IA-Alkyne can be used to develop an isotopically tagged probe for quantitative cysteine-reactivity profiling[2].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel
Research Areas >> Infection
Research Areas >> Inflammation/Immunology

[Target]

IC50: TRPC[1]


[In Vitro]

IA-alkyne (2.5-10 μM; 1 hour) can react with cysteines. Soluble fractions of HeLa cell lysates (2.0 mg/ml) are treated with IA-alkyne. Labeled proteome samples are conjugated with a fluorescent rhodamine-azide tag through CuAAC, and analyzed by SDS-PAGE. In-gel fluorescence imaging reveals that IA-alkyne has a strong fluorescent intensity[2].

[References]

[1]. David L. Use of trp channel agonists to treat infections. Patent US20130203715A1.

[2]. Zorin NA, et al. Inhibition by iodoacetamide and acetylene of the H-D-exchange reaction catalyzed by Thiocapsa roseopersicina hydrogenase. Eur J Biochem. 1996 Oct 15;241(2):675-81.

Chemical & Physical Properties

[ Molecular Formula ]:
C8H12INO

[ Molecular Weight ]:
265.09100

[ Exact Mass ]:
264.99600

[ PSA ]:
32.59000

[ LogP ]:
2.18140

Safety Information

[ Hazard Codes ]:
T+

Related Compounds