(E)-C-HDMAPP ammonium

Names

[ Name ]:
(E)-C-HDMAPP ammonium

Biological Activity

[Description]:

(E)-C-HDMAPP ammonium, is a potent phosphoantigen in ammonium form as well as a pyrophosphonate form of (E)-HDMAPP. (E)-C-HDMAPP is also an effective activator of γδ-T cells, induces T-cell stimulatory responses in vitro (EC50=0.91 nM for TNF-α release)[1][2].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

[Target]

TNFRSF1A

[In Vitro]

(E)-C-HDMAPP (化合物 5E) (2 μM) 增加原代多克隆人 Vγ9Vδ2 T 细胞中的 TNF-α 释放水平，并具有刺激性生物活性[1]。

[In Vivo]

(E)-C-HDMAPP (化合物 5E) (0.02-10 mg/kg；静脉注射；15 天) 显着增加食蟹猴模型中的 γδ 细胞[1]。 Animal Model: Nonhuman Primate Model in Cynomolgus[1] Dosage: 0.02 mg/kg, 0.1 mg/kg, 0.5 mg/kg, 2.5 mg/kg, 5 mg/kg, and 10 mg/kg Administration: Intravenous injection; once with daily s.c. low doses IL-2 to sustain γδ-T-cell proliferation, for 15 days Result: Significantly increased γδ-cells in vivo at 0.02 mg/kg. Reached maximal effect at 5 mg/kg and 10 mg/kg.

[References]

[1]. Boëdec A, et al. Synthesis and biological activity of phosphonate analogues and geometric isomers of the highly potent phosphoantigen (E)-1-hydroxy-2-methylbut-2-enyl 4-diphosphate. J Med Chem. 2008 Mar 27;51(6):1747-54.

Chemical & Physical Properties

[ Molecular Formula ]:
C₆H₁₄O₇P₂

[ Molecular Weight ]:
311.210

[ Exact Mass ]:
311.101135

[ PSA ]:
143.91000

[ LogP ]:
0.60980

(E)-C-HDMAPP ammonium

Names

Biological Activity

Chemical & Physical Properties

Related Compounds