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Rabeprazole D4

Names

[ CAS No. ]:
934295-48-4

[ Name ]:
Rabeprazole D4

[Synonym ]:
Rabeprazole-d4

Biological Activity

[Description]:

Rabeprazole D4 (LY307640 D4) is a deuterium labeled Rabeprazole. Rabeprazole is a second-generation proton pump inhibitor (PPI) that irreversibly inactivates gastric H+/K+-ATPase. Rabeprazole induces apoptosis. Rabeprazole acts as an uridine nucleoside ribohydrolase (UNH) inhibitor with an IC50 of 0.3 μM. Rabeprazole can be used for the research of gastric ulcerations and gastroesophageal reflux[1][2][3].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer
Research Areas >> Inflammation/Immunology
Signaling Pathways >> Membrane Transporter/Ion Channel >> Proton Pump

[Target]

Pump inhibitor (PPI); UNH[1] H+/K+-ATPase; Apoptosis[2]


[References]

[1]. Tara A Shea, et al. Identification of Proton-Pump Inhibitor Drugs That Inhibit Trichomonas Vaginalis Uridine Nucleoside Ribohydrolase. Bioorg Med Chem Lett. 2014 Feb 15;24(4):1080-4.

[2]. Mengli Gu, et al. Rabeprazole Exhibits Antiproliferative Effects on Human Gastric Cancer Cell Lines. Oncol Lett. 2014 Oct;8(4):1739-1744.

[3]. Aly A M Shaalan, et al. Supplement With Calcium or Alendronate Suppresses Osteopenia Due to Long Term Rabeprazole Treatment in Female Mice: Influence on Bone TRAP and Osteopontin Levels. Front Pharmacol. 2020 May 13;11:583.

Chemical & Physical Properties

[ Molecular Formula ]:
C18H17D4N3O3S

[ Molecular Weight ]:
359.44300

[ Exact Mass ]:
359.13000

[ PSA ]:
96.31000

[ LogP ]:
3.85510

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds