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TH-237A

Names

[ CAS No. ]:
935467-97-3

[ Name ]:
TH-237A

[Synonym ]:
TH 237A
[(3R,5S)-3,5-Bis(4-fluorophenyl)-1H-[1,3]oxazolo[3,4-c][1,3]oxazol-7a(7H)-yl]methanol
(3R,5S,7as)-[3,5-Bis(4-fluorophenyl)tetrahydro-1H-oxazolo[3,4-c]oxazol-7a-yl]methanol
1H,3H,5H-Oxazolo[3,4-c]oxazole-7a(7H)-methanol, 3,5-bis(4-fluorophenyl)-, (3R,5S)-
meso-GS 164
TH-237A

Biological Activity

[Description]:

TH-237A(meso-GS 164) is a novel neuroprotective agent exhibiting favorable permeation across the blood brain barrier.IC50 value: 5 nM (EC50, concentration that leads to a 50% increase in neuronal survival in the presence of the Aβ peptides)Target: Primary neurons were isolated from embryonic Sprague-Dawley rats, grown in culture (Michaelis et al., 1994) and exposed to either Aβ25-35 or Aβ1-42 in the presence or absence of TH-237A at concentrations ranging from 0.5 to 60 nM. The neurons were treated with TH-237A for 2 hours prior to exposure to the Aβ peptides. Changes in neuronal survival following treatment with TH 237A were evaluated using the Live/Dead assay. The EC50 for TH-237A was 5 nM, demonstrating that it had excellent neuroprotective properties.

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Neurological Disease

[References]

[1]. Kelly E. Desino, Improving Blood Brain Barrier Permeation of Small Molecules Exhibiting Chemotherapeutic and Neuroprotective Effects.


[Related Small Molecules]

Captisol | Cyclosporin A | H2DCFDA | 0MPTP hydrochloride | GW4869 | Etomoxir | TD139 | Mitoquinone mesylate | GSK2795039 | JC-1 | BAPTA-AM | AP 20187 | Setanaxib (GKT137831) | D-Luciferin | Crotaline

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
455.5±45.0 °C at 760 mmHg

[ Melting Point ]:
90 °C (hexane)

[ Molecular Formula ]:
C18H17F2NO3

[ Molecular Weight ]:
333.329

[ Flash Point ]:
229.3±28.7 °C

[ Exact Mass ]:
333.117645

[ PSA ]:
41.93000

[ LogP ]:
4.40

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.626

[ Storage condition ]:
2-8℃

Related Compounds