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mu-conotoxin

Names

[ CAS No. ]:
936616-33-0

[ Name ]:
mu-conotoxin

Biological Activity

[Description]:

μ-Conotoxin-CnIIIC is a 22-residue conopeptide that can be isolated from Conus consors. μ-Conotoxin-CnIIIC is a potent and persistent blocker of NaV1.4 channel. μ-Conotoxin-CnIIIC has analgesic, anaesthetic and myorelaxant properties[1][2].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel
Research Areas >> Inflammation/Immunology

[Target]

NaV1.4 Channel[2]


[References]

[1]. Markgraf R, et al. Mechanism and molecular basis for the sodium channel subtype specificity of µ-conopeptide CnIIIC. Br J Pharmacol. 2012 Oct;167(3):576-86.  

[2]. Del Río-Sancho S, et al. Cutaneous iontophoresis of μ-conotoxin CnIIIC-A potent NaV1.4 antagonist with analgesic, anaesthetic and myorelaxant properties. Int J Pharm. 2017 Feb 25;518(1-2):59-65.  

Chemical & Physical Properties

[ Density]:
1.71±0.1 g/cm3

[ Molecular Formula ]:
C92H139N35O28S6

[ Molecular Weight ]:
2375.70

Related Compounds