HDAC1,2-IN-2

A potent, selective HDAC1 and HDAC2 inhibitor with IC50 of 6 nM and 45 nM, respectively; displays highly selectivity over HDAC3 (IC50=7.0 μM), HDAC8 and 11 (IC50=20-25 uM) and no activity on HDACs 4-7; increases lysine 5 of histone H2B (H2BK5) in HCT116 colon carcinoma cells with IC50 of 400 nM, inhibited the cell growth with GI50 of 97 nM; exhibits tumor growth inhibition in HCT116 xenograft mice.

References 1. Hamblett CL, et al. Bioorg Med Chem Lett. 2007 Oct 1;17(19):5300-9. 2. Methot JL, et al. ACS Med Chem Lett. 2014 Jan 2;5(4):340-5. View Related Products by Target HDAC