N6,N6-dimethyladenine

Names

[ CAS No. ]:
938-55-6

[ Name ]:
N6,N6-dimethyladenine

[Synonym ]:
UNII:649SA4S2CV
7H-Purin-6-amine, N,N-dimethyl-
N,N-dimethyl-7H-purin-6-amine
N(6),N(6)-dimethyladenine
N,N-Dimethyl-1H-purin-6-amine
N,N-Dimethyl-6-aminopurine
EINECS 214-353-5
N6,N6-dimethyl-Adenine
1H-purin-6-amine, N,N-dimethyl-
Adenine, N6,N6-dimethyl-
6-(dimethylamino)-Purine
MFCD00005573
Dimethylaminopurine
6-Dimethylaminopurine
N,N-dimethyl-adenine

Biological Activity

[Description]:

6-(Dimethylamino)purine is a dual inhibitor of protein kinase and CDK[1][2].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Cell Cycle/DNA Damage >> CDK

[References]

[1]. Neant I, et al. 6-Dimethylaminopurine blocks starfish oocyte maturation by inhibiting a relevant protein kinase activity. Exp Cell Res. 1988 May;176(1):68-79.

[2]. Meijer L, et al. Properties and potential-applications of chemical inhibitors of cyclin-dependent kinases. Pharmacol Ther. 1999 May-Jun;82(2-3):279-84.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
427.4±25.0 °C at 760 mmHg

[ Melting Point ]:
259-262 °C(lit.)

[ Molecular Formula ]:
C₇H₉N₅

[ Molecular Weight ]:
163.180

[ Flash Point ]:
212.3±23.2 °C

[ Exact Mass ]:
163.085800

[ PSA ]:
57.70000

[ LogP ]:
1.43

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.718

[ Storage condition ]:
−20°C

[ Water Solubility ]:
methanol: 0.1 g/mL, clear

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
T+: Very toxic;

[ Risk Phrases ]:
R25

[ Safety Phrases ]:
S26-S28-S36/37/39-S45-S24/25-S22

[ RIDADR ]:
UN 2811 6.1/PG 1

[ WGK Germany ]:
3

[ RTECS ]:
US9230000

[ Packaging Group ]:
II; III

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Placental development during early pregnancy in sheep: effects of embryo origin on vascularization.

Reproduction 147(5) , 639-48, (2014)

Utero-placental growth and vascular development are critical for pregnancy establishment that may be altered by various factors including assisted reproductive technologies (ART), nutrition, or others...

A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.

Proc. Natl. Acad. Sci. U. S. A. 104 , 20523-8, (2007)

Protein kinases play a pivotal role in cell signaling, and dysregulation of many kinases has been linked to disease development. A large number of kinase inhibitors are therefore currently under inves...

Circadian rhythms. Decoupling circadian clock protein turnover from circadian period determination.

Science 347(6221) , 1257277, (2015)

The mechanistic basis of eukaryotic circadian oscillators in model systems as diverse as Neurospora, Drosophila, and mammalian cells is thought to be a transcription-and-translation-based negative fee...