(±)-N-3-Benzylnirvanol

Names

[ Name ]:
(±)-N-3-Benzylnirvanol

[Synonym ]:
3-Benzyl-5-aethyl-5-phenyl-hydantoin
3-Benzyl-5-ethyl-5-phenyl-hydantoi
3-Benzyl-5-ethyl-5-phenyl-hydantoin
3-benzyl-5-ethyl-5-phenyl-imidazolidine-2,4-dione
5-ethyl-3-benzyl-5-phenyl-imidazolidine-2,4-dione
(+/-)-N-3-benzyl-Nirvanol
5-Ethyl-5-phenyl-3-(phenylmethyl)-2,4-imidazolidinedione
5-Aethyl-3-benzyl-5-phenyl-imidazolidin-2,4-dion

Biological Activity

[Description]:

(±)-N-3-Benzylnirvanol is a racemic mixture of (+)-N-3-Benzylnirvanol and (-)-N-3-Benzylnirvanol. (+)-N-3-Benzylnirvanol and (–)-N-3-Benzylnirvanol are potent and selective cytochrome P450 inhibitors with Ki values of 0.25 and 5.3 μM for CYP2C19, respectively[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450

Research Areas >> Metabolic Disease

[References]

[1]. Hisashi Suzuki, et al. (+)-N-3-Benzyl-nirvanol and (-)-N-3-benzyl-phenobarbital: new potent and selective in vitro inhibitors of CYP2C19. Drug Metab Dispos. 2002 Mar;30(3):235-9.

Chemical & Physical Properties

[ Density]:
1.19g/cm3

[ Melting Point ]:
134-136ºC

[ Molecular Formula ]:
C₁₈H₁₈N₂O₂

[ Molecular Weight ]:
294.34800

[ Exact Mass ]:
294.13700

[ PSA ]:
49.41000

[ LogP ]:
3.31060

[ Index of Refraction ]:
1.593

[ Storage condition ]:
-20°C

Safety Information

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%