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MDM2-IN-21

Names

[ CAS No. ]:
939981-88-1

[ Name ]:
MDM2-IN-21

Biological Activity

[Description]:

MDM2-IN-21 is a potent MDM2 inhibitor. MDM2-IN-21 can be used for the research of cancer[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Apoptosis >> MDM-2/p53

[Target]

MDM2[1]

[In Vitro]

The IC50 values of MDM2-IN-21 are 0.03 μM and 0.8 μM in homogeneous time resolved fluorescence (HTRF) assay and the wild-type p53 cell lines[1].

[References]

[1]. Vu B, et al. Discovery of RG7112: A Small-Molecule MDM2 Inhibitor in Clinical Development. ACS Med Chem Lett. 2013;4(5):466-469.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₄H₄₀Cl₂N₄O₂

[ Molecular Weight ]:
607.61

Related Compounds