L-Homopropargylglycine hydrochloride

Names

[ Name ]:
L-Homopropargylglycine hydrochloride

[Synonym ]:
MFCD31619332
(2S)-2-Amino-5-hexynoic acid hydrochloride (1:1)
5-Hexynoic acid, 2-amino-, (2S)-, hydrochloride (1:1)

Biological Activity

[Description]:

L-Homopropargylglycine hydrochloride is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. L-homopropargylglycine hydrochloride is an amino acid analog of methionine containing an alkyne moiety that can undergo a classic click chemical reaction with azide containing Alexa Fluor[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl-Chain

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018;36:553-562.

[2]. Shen Y, et al. Protocol for visualizing newly synthesized proteins in primary mouse hepatocytes. STAR Protoc. 2021;2(3):100616. Published 2021 Jun 17.

Chemical & Physical Properties

[ Molecular Formula ]:
C₆H₁₀ClNO₂

[ Molecular Weight ]:
163.60

[ Exact Mass ]:
163.040009

[ Storage condition ]:
-20°C

L-Homopropargylglycine hydrochloride

Names

Biological Activity

Chemical & Physical Properties

Related Compounds