Efortil
Names
[ CAS No. ]:
943-17-9
[ Name ]:
Efortil
[Synonym ]:
etilefrine hydrochloride
Effortil
α-[(Ethylamino)methyl]-3-hydroxybenzenemethanol hydrochloride
N-Ethyl-1-(m-hydroxyphenyl)-2-aminoethanol hydrochloride
3-[2-(ethylamino)-1-hydroxyethyl]phenol hydrochloride
Thomasin
Benzenemethanol, α-[(ethylamino)methyl]-3-hydroxy-, hydrochloride (1:1)
Effortil*HCl
EINECS 213-398-8
Etilefrin-HCl
3-[2-(Ethylamino)-1-hydroxyethyl]phenol hydrochloride (1:1)
Etilefrin dl-form hydrochloride
Cardanat
Etilefrine HCl
Effontil
Efortil
Circupon
Biological Activity
[Description]:
[Related Catalog]:
[References]
Chemical & Physical Properties
[ Density]:
1.127g/cm3
[ Boiling Point ]:
351.7ºC at 760 mmHg
[ Melting Point ]:
122ºC
[ Molecular Formula ]:
C10H16ClNO2
[ Molecular Weight ]:
217.69
[ Flash Point ]:
155.5ºC
[ Exact Mass ]:
217.086960
[ PSA ]:
52.49000
[ LogP ]:
2.22800
[ Water Solubility ]:
Freely soluble in water, soluble in ethanol (96 per cent), practically insoluble in methylene chloride
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- DO5618000
- CHEMICAL NAME :
- Benzyl alcohol, alpha-((ethylamino)methyl)-m-hydroxy-, hydrochloride
- CAS REGISTRY NUMBER :
- 943-17-9
- LAST UPDATED :
- 199806
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C10-H15-N-O2.Cl-H
- MOLECULAR WEIGHT :
- 217.72
- WISWESSER LINE NOTATION :
- QR CYQ1M2 &GH
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 187 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 4,413,1979
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >420 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,187,1990
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,225,1995
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 345 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 4,413,1979
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 860 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,115,1982
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 11 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 4,413,1979
Safety Information
[ Symbol ]:
GHS06
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H301-H319
[ Precautionary Statements ]:
Missing Phrase - N15.00950417-P305 + P351 + P338
[ RIDADR ]:
UN 2811 6.1 / PGIII
[ RTECS ]:
DO5618000
[ HS Code ]:
2922509090
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2922509090
[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
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To describe surgical technique and outcome after laparoscopic closure of the nephrosplenic space for treatment of recurrent left dorsal displacement of the left colon (LDDLC) in standing horses.Retros...
[A complicated course after esophagogastrectomy].J. Chir. (Paris.) 144(3) , 241-5, (2007)
Priapism in a patient with unstable hemoglobin: hemoglobin Köln.
Am. J. Hematol. 74(1) , 73-4, (2003)
We report a case of severe priapism occurring in a patient with unstable hemoglobin, hemoglobin Köln, and underline several factors that may have contributed to this complication: abnormal plasticity ...