(+)-Biotin-PEG2-azide

Names

[ CAS No. ]:
945633-30-7

[ Name ]:
(+)-Biotin-PEG2-azide

[Synonym ]:
(+)-Biotin-PEG3-CH2CH2N3
(+)-Biotin-PEG3-azide
(+)-Biotin-PEG3-CH2CH2azide

Biological Activity

[Description]:

Biotin-PEG2-CH2CH2N3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₂₈N₆O₄S

[ Molecular Weight ]:
400.49600

[ Exact Mass ]:
400.18900

[ PSA ]:
163.74000

[ LogP ]:
1.67316

[ Storage condition ]:
-20°C

(+)-Biotin-PEG2-azide

Names

Biological Activity

Chemical & Physical Properties

Related Compounds