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dynorphin (1-11), Pro(10)-

Names

[ CAS No. ]:
94596-26-6

[ Name ]:
dynorphin (1-11), Pro(10)-

[Synonym ]:
DYNORPHIN (1-11),PRO(10)-
YGGFLRRIRDPK
α-Neoendorphin (pig), 7-L-arginine-8-L-isoleucine-8a-endo-L-arginine-9-D-proline-

Biological Activity

[Description]:

[DPro10] Dynorphin A (1-11), porcine, a N-Alkylated derivative, is a potent κ-opioid receptor agonist with a Ki value of 0.13 nM. [DPro10] Dynorphin A (1-11), porcine has analgesic property[1][2].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Opioid Receptor
Signaling Pathways >> GPCR/G Protein >> Adenylate Cyclase
Signaling Pathways >> Neuronal Signaling >> Opioid Receptor
Research Areas >> Neurological Disease

[In Vitro]

[DPro10] Dynorphin A (1-11), porcine has inhibition of adenylyl cyclase activity in k-opioid receptor-expressing CHO cells with an IC50 value of 0.12 nM[1].

[In Vivo]

[DPro10] Dynorphin A (1-11), porcine (ICV) has analgesic effects involving thermal cutaneous (tail-flick) and chemical visceral (AcOH-induced writhing) stimuli, in which mu and kappa receptors are known to be activated differentially[2].

Chemical & Physical Properties

[ Density]:
1.42±0.1 g/cm3 (20 °C, 760 mmHg)

[ Molecular Formula ]:
C63H103N21O13

[ Molecular Weight ]:
1362.62000

[ Exact Mass ]:
1361.80000

[ PSA ]:
577.48000

[ LogP ]:
4.64670

Related Compounds