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MNI 137

Names

[ CAS No. ]:
946619-21-2

[ Name ]:
MNI 137

[Synonym ]:
MNI 137
VU 0360172 hydrochloride

Biological Activity

[Description]:

MNI137 is a potent and selective negative allosteric modulator for group II mGluRs. MNI137 has IC50s values of 8.3 and 12.6 nM for human and rat mGlu2 inhibition of glutamate-induced calcium mobilization[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> mGluR
Research Areas >> Neurological Disease

[References]

[1]. Hemstapat K, et al. A novel family of potent negative allosteric modulators of group II metabotropic glutamate receptors. J Pharmacol Exp Ther. 2007;322(1):254-264.

Chemical & Physical Properties

[ Density]:
1.62±0.1 g/cm3 (20 °C, 760 mmHg)

[ Boiling Point ]:
561.2±50.0 °C (760 mmHg)

[ Molecular Formula ]:
C15H9BrN4O

[ Molecular Weight ]:
341.16200

[ Exact Mass ]:
339.99600

[ PSA ]:
78.14000

[ LogP ]:
2.75238

Related Compounds