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Phytochelatin 2 (PC2)

Names

[ CAS No. ]:
95014-75-8

[ Name ]:
Phytochelatin 2 (PC2)

[Synonym ]:
PC2
γGlu-Cys-γGlu-Cys-Gly
H-(γ-Glu-Cys)2-Gly-OH
H-(γ-Glu-Cys)2-Gly-OH
(γ-Glu-Cys)2-Gly
Cadystin (γEC)2G

Biological Activity

[Description]:

Phytochelatin 2, a short phytochelatin, is a key plant peptide binding heavy metals. Phytochelatins are a diverse set of plant compounds that chelate metals, protect against metal toxicity and function in metal homeostasis[1][2].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Others >> Others

[In Vitro]

Phytochelatin synthase (PCS) uses the substrates glutathione (GSH, γGlu-Cys-Gly) and a cadmium (Cd)-bound GSH (Cd∙GS2) to produce the shortest phytochelatin product (PC2, (γGlu-Cys)2-Gly) through a ping-pong mechanism[3]. Phytochelatins and their glutathione (GSH) precursor are thiol-rich peptides that play an important role in heavy metal detoxification in plants and microorganisms[4].

[References]

[1]. phytochelatin, heavy, metals, chelate, homeostasis, glutathione, microorganisms, toxicity

[2]. Dennis KK, et al. Phytochelatin database: a resource for phytochelatin complexes of nutritional and environmental metals. Database (Oxford). 2019;2019:baz083.

[3]. Chia JC, et al. Tentative identification of the second substrate binding site in Arabidopsis phytochelatin synthase. PLoS One. 2013;8(12):e82675. Published 2013 Dec 5.

[4]. Jacquart A, et al. Cd2+ and Pb2+ complexation by glutathione and the phytochelatins. Chem Biol Interact. 2017;267:2-10.

Chemical & Physical Properties

[ Molecular Formula ]:
C18H29N5O10S2

[ Molecular Weight ]:
539.58000

[ Exact Mass ]:
539.13600

[ PSA ]:
331.92000

Related Compounds