PC190723

Names

[ Name ]:
PC190723

[Synonym ]:
9pc

Biological Activity

[Description]:

PC190723 (Compound 2) is an inhibitor of the bacterial cell division protein FtsZ with an IC50 of 55 ng/ml. FtsZ-IN-3 exhibits anti-staphylococcal activity with MIC values of 1 µg/ml for MSSA and MRSA[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[Target]

IC50: 55 ng/ml (FtsZ)[1]

[References]

[1]. Buroni S, et al. The cell division protein FtsZ as a cellular target to hit cystic fibrosis pathogens. Eur J Med Chem. 2020 Mar 15;190:112132.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₄H₈ClF₂N₃O₂S

[ Molecular Weight ]:
355.75

[ Exact Mass ]:
354.99900

[ PSA ]:
106.34000

[ LogP ]:
4.00110