TP748

Names

[ Name ]:
TP748

[Synonym ]:
5-Isoxazolemethanamine, α-ethenyl-N,N-dimethyl-3-(phenylmethoxy)-, (αS)-
(1S)-1-[3-(Benzyloxy)-1,2-oxazol-5-yl]-N,N-dimethyl-2-propen-1-amine

Biological Activity

[Description]:

TP748,an isoxazole, is a key intermediate for fully synthetic tetracyclines[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vitro]

A robust, cost effective and high yielding manufacturing process for enantiomerically enriched (S)-allylic amine 3, a key intermediate for fully synthetic tetracyclines have been developed[1].

[References]

[1]. Wu-Yan Zhang, et al. Process Research and Development of TP-808: A Key Intermediate for the Manufacture of Synthetic Tetracyclines. Process Res. Dev. 2017, 21, 3, 377-386.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
367.3±42.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₅H₁₈N₂O₂

[ Molecular Weight ]:
258.316

[ Flash Point ]:
176.0±27.9 °C

[ Exact Mass ]:
258.136841

[ PSA ]:
38.50000

[ LogP ]:
2.95

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.547

[ Storage condition ]:
-20°C