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VK-II-86

Names

[ CAS No. ]:
955371-84-3

[ Name ]:
VK-II-86

[Synonym ]:
2-Butanol, 4-(9H-carbazol-4-yloxy)-1-[[2-(2-methoxyphenoxy)ethyl]amino]-
4-(9H-Carbazol-4-yloxy)-1-{[2-(2-methoxyphenoxy)ethyl]amino}-2-butanol
VK-II-86

Biological Activity

[Description]:

VK-II-86 is a Carvedilol (HY-B0006) analogue lacking antagonist activity at β-adrenoceptors, in hypokalaemia. VK-II-86 prevents hypokalaemia-induced ventricular arrhythmia through multi-channel effects. VK-II-86 prevents all hypokalaemia-induced changes in ion channel activity and oxidative stress[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> Others >> Others

[In Vivo]

VK-II-86 在低钾血症小鼠全心模型中显著减少非持续性和持续性室性快速心律失常的数量[1]。

[References]

[1]. Robinson VM, et al. A carvedilol analogue, VK-II-86, prevents hypokalaemia-induced ventricular arrhythmia through novel multi-channel effects. Br J Pharmacol. 2022 Jun;179(11):2713-2732.  

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
660.6±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C25H28N2O4

[ Molecular Weight ]:
420.501

[ Flash Point ]:
353.3±31.5 °C

[ Exact Mass ]:
420.204895

[ LogP ]:
4.93

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.648

Related Compounds