2’-Bromo-2’-deoxy-5-methyluridine

Names

[ CAS No. ]:
95585-76-5

[ Name ]:
2’-Bromo-2’-deoxy-5-methyluridine

[Synonym ]:
2-Brom-thiophen-3-carboxamid
2'-bromo-5-methyl-2'-deoxy-uridine
2-Brom-thiophen-3-carbonsaeure-amid
2-bromo-thiophene-3-carboxylic acid amide
2'-Brom-thymidin

Biological Activity

[Description]:

2’-Bromo-2’-deoxy-5-methyluridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

Chemical & Physical Properties

[ Molecular Formula ]:
C10H13BrN2O5

[ Molecular Weight ]:
321.12

[ Exact Mass ]:
320.00100

[ PSA ]:
104.81000

Synthetic Route

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