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3MB-PP1

Names

[ CAS No. ]:
956025-83-5

[ Name ]:
3MB-PP1

[Synonym ]:
2wei
VGG

Biological Activity

[Description]:

3MB-PP1, a bulky purine analog, is a Polo-like kinase 1 (Plk1) inhibitor. 3MB-PP1 blocks mitotic progression and cell division arise through target Plk1 in in cells expressing analog-sensitive Plk1 alleles. 3MB-PP1 specifically inhibits the activity of analog-sensitive Ssn3 (Cdk8). 3MB-PP1 inhibits Leu93 Mutant Zipper-interacting protein kinase (Leu93-ZIPK; IC50=2 μM). 3MB-PP1 can be used for the research of hypha formation of Candida albicans and cell division[1][2][3].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Apoptosis >> DAPK
Signaling Pathways >> Cell Cycle/DNA Damage >> Polo-like Kinase (PLK)
Signaling Pathways >> Cell Cycle/DNA Damage >> CDK

[Target]

Leu93-ZIPK:2 μM (IC50)


[In Vitro]

3MB-PP1 (5 μM; 3 hours) stimulates hyphal growth in a strain bearing analog-sensitive alleles of SSN3[1].

[References]

[1]. Burkard ME, et al. Enabling and disabling polo-like kinase 1 inhibition through chemical genetics. ACS Chem Biol. 2012 Jun 15;7(6):978-81.

[2]. Hollomon JM, et al. The Candida albicans Cdk8-dependent phosphoproteome reveals repression of hyphal growth through a Flo8-dependent pathway. PLoS Genet. 2022;18(1):e1009622. Published 2022 Jan 4.

[3]. Al-Ghabkari A, et al. Validation of chemical genetics for the study of zipper-interacting protein kinase signaling. Proteins. 2018 Nov;86(11):1211-1217.

Chemical & Physical Properties

[ Density]:
1.209g/cm3

[ Boiling Point ]:
475.471ºC at 760 mmHg

[ Melting Point ]:
136-138ºC

[ Molecular Formula ]:
C17H21N5

[ Molecular Weight ]:
295.38200

[ Flash Point ]:
241.356ºC

[ Exact Mass ]:
295.18000

[ PSA ]:
69.62000

[ LogP ]:
3.64390

[ Index of Refraction ]:
1.64

Related Compounds