TCS HDAC6 20b

Names

[ Name ]:
TCS HDAC6 20b

[Synonym ]:
Propanethioic acid, 2-methyl-, S-[(6S)-6-[[(1,1-dimethylethoxy)carbonyl]amino]-7-oxo-7-(tricyclo[3.3.1.13,7]dec-1-ylamino)heptyl] ester
S-[(6S)-7-(Adamantan-1-ylamino)-6-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)-7-oxoheptyl] 2-methylpropanethioate
S-[(6S)-6-[(tert-butoxycarbonyl)amino]-7-oxo-7-(tricyclo[3.3.1.13,7]dec-1-ylamino)heptyl] 2-methylpropanethioate
TCS HDAC6 20b

Biological Activity

[Description]:

TCS HDAC6 20b is a HDAC6-selective inhibitor. TCS HDAC6 20b blocks the growth of estrogen receptor α-positive breast cancer MCF-7 cells[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC

Signaling Pathways >> Epigenetics >> HDAC

[References]

[1]. Yukihiro Itoh, et al. Design, synthesis, structure--selectivity relationship, and effect on human cancer cells of a novel series of histone deacetylase 6-selective inhibitors. J Med Chem. 2007 Nov 1;50(22):5425-38.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
631.3±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₆H₄₄N₂O₄S

[ Molecular Weight ]:
480.704

[ Flash Point ]:
335.6±31.5 °C

[ Exact Mass ]:
480.302185

[ LogP ]:
5.66

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.537

TCS HDAC6 20b

Names

Biological Activity

Chemical & Physical Properties

Related Compounds